Binding of LPS to Neutrophils
and Release of Killing Agents
The LPS released from
the Gram-negative cell wall binds to LPS receptors on the surface of defense
cells such as monocytes, macrophages and neutrophils. This is a normal component
of body defense and is one of the mechanisms by which the body is able to recognize
that Gram-negative bacteria have invaded the body. The
binding of LPS to the LPS receptors and IL-8 to IL-8 receptors on the surface
of neutrophils stimulates them to release proteases and toxic oxygen radicals
for extracellular killing.
Microbiology Laboratory Manual by Gary E. Kaiser, PhD, Professor of Microbiology
is licensed under a Creative Commons Attribution 4.0 International License.
Last updated: September, 2017