Binding of LPS to Neutrophils and Release of Killing Agents

The LPS released from the Gram-negative cell wall binds to LPS receptors on the surface of defense cells such as monocytes, macrophages and neutrophils. This is a normal component of body defense and is one of the mechanisms by which the body is able to recognize that Gram-negative bacteria have invaded the body. The binding of LPS to the LPS receptors and IL-8 to IL-8 receptors on the surface of neutrophils stimulates them to release proteases and toxic oxygen radicals for extracellular killing.

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Microbiology Laboratory Manual by Gary E. Kaiser, PhD, Professor of Microbiology
is licensed under a Creative Commons Attribution 4.0 International License.
Last updated: September, 2017