Capsules Resisting Unenhanced Attachment of Pathogen-Associated Molecular Patterns by Endocytic Pattern-Recognition Receptors on Phagocytes

Glycoprotein molecules known as endocytic pattern-recognition receptors are found on the surface of phagocytes. They are so named because they recognize and bind to pathogen-associated molecular patterns - molecular components associated with microorganisms but not found as a part of eukaryotic cells. These include bacterial molecules such as peptidoglycan, lipoteichoic acids, and lipopolysaccharide (LPS). These receptors enable the phagocyte to attach to the cell wall of the microorganism so it can be engulfed and destroyed by lysosomes. Capsules can cover the pathogen-associated molecular patterns blocking their binding to endocytic pattern-recognition receptors.

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