Bacterial Resistance to Antibiotics:
Producing an Altered Target Site to which the Antibiotic No Longer Binds
Some antibiotics work by binding to a bacterial ribosomal subunit, altering the ribosome, and blocking bacterial protein synthesis. This bacterium becomes resistant to the antibiotic by altering the antibiotic's target site, in this case a 50S ribosomal subunit. The drug is no longer able to bind to the ribosome and the bacterium can still carry out normal protein synthesis.