Mode of Action of Macrolides in Blocking
Translation during Bacterial Protein Synthesis: Blocking Peptidyltransferase

The macrolides (erythromycin, azithromycin, clarithromycin, dirithromycin, troleandomycin, etc.) bind reversibly to the 23S rRNA in the 50S subunit.There is evidence that they may inhibit elongation of the protein by the peptidyltransferase, the enzyme that forms peptide bonds between the amino acids.

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