Fig. 16: Mode of Action of Macrolides in Blocking
Translation during Bacterial Protein Synthesis: Blocking Peptidyltransferase

The macrolides (erythromycin, azithromycin, clarithromycin, dirithromycin, troleandomycin, etc.) bind reversibly to the 23S rRNA in the 50S subunit.There is evidence that they may inhibit elongation of the protein by the peptidyltransferase, the enzyme that forms peptide bonds between the amino acids.


Illustration of the Mode of Action of Macrolides in Blocking Translation during Bacterial Protein Synthesis: Blocking Peptidyltransferase.jpg by Gary E. Kaiser, Ph.D.
Professor of Microbiology, The Community College of Baltimore County, Catonsville Campus
This work is licensed under a Creative Commons Attribution 4.0 International License.
Based on a work at http://faculty.ccbcmd.edu/~gkaiser/index.html.

Creative Commons License

Last updated: September, 2018
Please send comments and inquiries to Dr. Gary Kaiser