Mode of Action of Macrolides in Blocking Translation during Bacterial Protein Synthesis: Preventing the Transfer of the Peptidyl tRNA from the A-site to the P-site

The macrolides (erythromycin, azithromycin, clarithromycin, dirithromycin, troleandomycin, etc.) bind reversibly to the 23S rRNA in the 50S subunit. There is evidence that they may inhibit elongation of the protein by preventing the enzyme peptidyltransferase from forming peptide bonds between the amino acids. They may also prevent the transfer of the peptidyl tRNA from the A-site to the P-site as shown here.

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