I. BACTERIAL PATHOGENESIS

A. Overview and Quorum Sensing

B. Virulence Factors that Promote Bacterial Colonization of the Host

1. The Ability to Use Motility and Other Means to Contact Host Cells

2. The Ability to Adhere to Host Cells and Resist Physical Removal

3. The Ability to Invade Host Cells

4. The Ability to Compete for Iron and Other Nutrients

5. The Ability to Resist Innate Immune Defenses such as Phagocytosis, Complement, and Antibacterial Peptides

a. An Overview

b. The Ability to Resist Phagocytic Engulfment (Attachment and Ingestion) and Antibacterial Peptides

c. The Ability to Resist Phagocytic Destruction

6. The Ability to Evade Adaptive Immune Defenses

C. Virulence Factors that Damage the Host: An Overview

1. The Ability to Produce Cell Wall Components that Bind to Host Cells causing them to Synthesize and Secrete Inflammatory Cytokines and Chemokines

a. Overview

b. Gram-Negative Cell Wall Components

c. Gram-Positive Cell Wall Components

d. Acid-Fast Cell Wall Components

2. The Ability to Produce Harmful Exotoxins: An Overview

a. Type I Toxins: Superantigens

b. Type II Toxins: Toxins that Damage Host Cell Membranes

c. Type III Toxins: A-B Toxins and other Toxins that Interfere with Host Cell Function

3 . The Ability to Induce Autoimmune Responses

II. USING ANTIBIOTICS AND CHEMICAL AGENTS TO CONTROL BACTERIA

A. An Overview

B. Ways in which Control Agents Affect Bacterial Structures or Functions

C. Ways in which Bacteria May Resist Our Control Agents

 

BIOL 230 Lectures: Unit 2 Table of Contents BIOL 230 Lectures: Table of Contents BIOL 230 Lab Manual: Table of Contents Doc Kaiser's Microbiology Web Site BIOL 230 WWW Web Page Biology Tutorials