Fig. 5: ADP- Ribosylation of a Target Host Protein by an A-B Toxin

The A component of most A-B toxins catalyzes ADP-ribosylation of host cell target proteins. The ADP-ribosyl group is removed from the coenzyme NAD (see dashed line) and is covalently attached to a host cell target protein. This causes the inactivation of that target protein.

© Gary E. Kaiser
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Updated: February 23, 2001
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