Objectives for "Bacterial Pathogenesis: Factors that Damage the Host"
1. The Ability of PAMPs to Trigger the Production of Inflammatory Cytokines that Result in an Excessive Inflammatory Response
a. Overall Mechanism
After completing this section you should be able to perform the following objectives.
1*. Define cytokine and chemokine and name 3 inflammatory cytokines.
2*. State the mechanism forinflammation and state why it is primarily beneficial to the body.
3*. Briefly describe why inflammation during a minor or moderate infection is essentially beneficial while inflammation during a massive infection can cause considerable damage to the body.
4**. Looking at the overall mechanism behind septic shock, answer the following:
1. Describe how bacterial PAMPS initiate SIRS.
2. Define hypotension and describe the biological mechanism behind 3 factors that contribute to hypotension.
3. Define hypovolemia and describe the biological mechanism behind 3 factors that contribute to hypovolemia.
4. Define hypoperfusion and describe the biological mechanism behind at least 3 factors that contribute to hypoperfusion.
5. Describe the biological mechanism behind ARDS and how ARDS contributes to hypoperfusion.
6. Describe the sequence of events that enables hypoperfusion to lead to irreversible cell damage.
5*. Define pyroptosis and inflammasome and state their role in inducing inflammation.
6**. Define the following:
E. septic shock
(*) = Common theme throughout the course
(**) = More depth and common theme
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Updated: Oct., 2015
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