Fig. 4A: HIV Protease, Step-1
HIV must use a HIV encoded enzyme
called protease in order to cleave a large Gag-Pol polyprotein (p120), a Gag
polyprotein (p55), and an Env polyprotein (gp160) into functional proteins essential
to the structure of HIV and to its RNA packaging. The active site of the HIV
protease binds to the polyproteins and cleaves them into functional proteins
- The Gag polyproteins (p55) will
eventually be cleaved by HIV proteases to become HIV matrix proteins (MA;
p17), capsid proteins (CA; p24), and nucleocapsid proteins (NC, p7).
- The Gag-Pol polyproteins (p160)
will eventually be cleaved to become HIV matrix proteins (MA; p17), capsid
proteins (CA; p24), proteinase molecules (protease or PR; p10), reverse transcriptase
molecules (RT; p66/p51), and integrase molecules (IN; p32).
Env polyproteins (gp160) will eventually be cleaved to become HIV envelope
glycoproteins gp120 and gp41.
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