HIV Protease

HIV must use a HIV encoded enzyme called protease in order to cleave a large Gag-Pol polyprotein (p120), a Gag polyprotein (p55), and an Env polyprotein (gp160) into functional proteins essential to the structure of HIV and to its RNA packaging. The active site of the HIV protease binds to the polyproteins and cleaves them into the functional proteins needed for viral replication and maturation.


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