Fig. 7: NK Cell Interacting with
a Virus-Infected Cell or a Mutant Cell
Not Expressing MHC-I Molecules
Viruses and malignant
transformation can sometimes interfere with the ability of the infected cell
or tumor cell to express MHC-I molecules. Without the signal from the killer-inhibitory
receptor, the kill signal from the killer-activating signal is not overridden
and the NK cell kills the cell to which it has bound.
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Updated: May 15, 2001
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