Fig. 3A: Cleavage of C2 by C1 during the Classical Complement Pathway - Step 1

C2 binds to the C4b and the enzyme C1 subsequently cleaves C2 into C2a and C2b. The C4b2a functions as a C3 convertase that can enzymatically cleave hundreds of molecules of C3 into C3a and C3b.

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