During phagosome formation, an electron pump brings protons (H+) into the phagosome. This lowers the pH within the phagosome so that when a lysosome fuses with the phagosome, the pH is correct for the acid hydrolases to effectively break down cellular proteins. Some bacteria prevent the acidification of the phagosome that is needed for effective killing of microbes by lysosomal enzymes.
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Updated: August, 2010
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