Fig. 6: Cleavage of C2 and Formation of C3 Convertase during the Classical Complement Pathway

C2 binds to the C4b and the enzyme C1 subsequently cleaves C2 into C2a and C2b. The classical complement pathway is now activated. The C4b2a functions as a C3 convertase that can enzymatically cleave hundreds of molecules of C3 into C3a and C3b.

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