A Proteasome Degrading Proteins into Peptides

During the replication of viruses and intracellular bacteria within their host cell, as well as during the replication of tumor cells, viral, bacterial, or tumor proteins, as well proteins released from phagosomes of phagocytes and various human cell or self-proteins, are degraded into a variety of peptide epitopes by cylindrical organelles called proteasomes. As endogenous antigens pass through proteasomes, proteases and peptidases chop the protein up into a series of peptides, typically 8-11 amino acids long.


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