Fig. 4: Cytotoxic T-lymphocyte (CTL)-Induced Apoptosis of a Virus-Infected Cell

Binding of the CTL to the infected cell triggers the CTL to release pore-forming proteins called perforins, proteolytic enzymes called granzymes, and chemokines. Granzymes pass through the pores and activate the caspase enzymes that lead to apoptosis of the infected cell by means of destruction of its structural cytoskeleton proteins and by chromosomal degradation. As a result, the cell breaks into fragments that are subsequently removed by phagocytes.

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