Fig. 2: IgE Binding to Mast Cells and Basophils and Promoting an Inflammatory Response

The Fc portion of IgE is able to bind to receptors on mast cells and basophils. The cross-binding of antigens to the Fab portion of IgE triggers the release of inflammatory mediators. The resulting inflammatory response subsequently delivers defense cells and defense molecules from the bloodstream to the infection site.

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