Fig. 8: Cross-Presentation of Endogenous Antigens to MHC-II Molecules
by a Dendritic Cell Through Autophagy

Endogenous antigens can be cross-presented to MHC-II molecules by certain dendritic cells through a cellular process called autophagy.

1. Cellular cytoplasm containing endogenous antigens is engulfed and placed in a autophagosome.
2. After a lysosome fuses with the autophagosome, these
endogenous proteins are degraded by lysosomal proteases into peptides.
3. The peptides are directly transfered from the autophagolysosome to the vesicles containing the MHC-II molecules.
4. The MHC-II molecules with bound peptides are then transported to the surface of the dendritic cell where they can be presented to naive T4-lymphocytes.


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