An MHC- II Molecule on an Antigen-Presenting Dendritic Cell Presenting a Bound Viral Epitope to a Naive T4-Lymphocyte with a Matching TCR/CD4 on its Surface

A naive T4-lymphocyte uses its TCR and CD4 molecules to bind to complementary shaped MHC-II molecule with attached peptide epitope on an antigen-presenting dendritic cell. As naive T4-lymphocytes migrate through the cortical region of lymph nodes, they use surface cell adhesion molecules such as LFA-1 and CD2 to bind transiently to corresponding receptors such as ICAM-1, ICAM-2 and CD58 on the surface of dentritic cells. This transient binding allows time for the TCRs on the T4-lymphocyte to sample large numbers of MHC-II/peptide complexes on the antigen-presenting dendritic cells.


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