An MHC- I Molecule on an Antigen-Presenting Dendritic Cell Presenting a Bound Viral Epitope to a Naive T8-Lymphocyte with a Matching TCR/CD8 on its Surface

A naive T8-lymphocyte uses its TCR and CD8 molecules to bind to complementary shaped MHC-I molecule with attached peptide epitope on an antigen-presenting dendritic cell. As naive T8-lymphocytes migrate through lymphoid tissues, they use surface cell adhesion molecules such as LFA-1 and CD2 to bind transiently to corresponding surface receptors such as ICAM-1, ICAM-2 and CD58 on dentritic cells. This transient binding allows time for the TCRs on the T8-lymphocyte to sample large numbers of MHC-I/peptide complexes on the dendritic cells.

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