Fig. 3: Diagram of a Peyer's Patch


Peyer's patches are part of the mucosa-associated lymphoid tissue (MALT) in the small intestines. Microbes and antigens enter through specialized epithelial cells called microfold (M) cells. Changing populations of naive B-lymphocytes and naive T-lymphocytes enter the Peyer's patch via blood vessels with B-lymphocytes entering the follicles and germinal centers and T-lymphocytes entering the T-cell area. Dendritic cells engulf and process antigens and present them by way of MHC molecules to the TCRs of naive T-lymphocytes.

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