Fig. 2: B-lymphocyte and T-Lymphocytes Recognizing Antigens in a Lymph Node

Opsonized antigens (those coated with C3b and Ced from the complement pathways) enter a lymph node through afferent lymphoid vessels. These opsonized antigens bind to and remain on the surface of specialized macrophages and follicular dendritic cells (FDCs). In addition, macrophages can transfer antigens to FDCs (see 4. above). Using their B-cell receptor (BCR), naive B-lymphocytes are able to recognize antigens directly (see 1. above), or more commonly, on the surface of FDCs (see 2. above), or on the surface of macrophages (see 3. above) in the germinal centers and lymphoid follicles of the lymph node. Meanwhile, naive T-lymphocytes are being activated by antigen-presenting dendritic cells in the T-cell areas of the lymph node (see 5. above). T4-effector cells and activated B-lymphcytes then interact with one another at the interface between the geminal centers and the T-cell areas.

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