Fig. 4: Transient binding of T8-Lymphocytes to Dendritic Cells

As naive T8-lymphocytes migrate through the cortical region of lymph nodes, they use surface cell adhesion molecules such as LFA-1 and CD2 to bind transiently to corresponding receptors such as ICAM-1, ICAM-2 and CD58 on the surface of dentritic cells. This transient binding allows time for the TCRs on the T8-lymphocyte to sample large numbers of MHC-I/peptide complexes on the antigen-presenting dendritic cells.

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